Die Space-Shuttle-Missionen der NASA waren zwischen 1981 und 2011 ein zentraler Bestandteil der bemannten Raumfahrt. Insgesamt wurden 135 Flüge durchgeführt, bei denen Satelliten ausgesetzt, wissenschaftliche Experimente durchgeführt und die Internationale Raumstation (ISS) aufgebaut und versorgt wurden. Das wiederverwendbare Shuttle ermöglichte auch Reparaturen im All, etwa am Hubble-Weltraumteleskop. Zwei Tragödien überschatteten das Programm: Challenger (1986) und Columbia (2003). Mit der Mission STS-135 endete das Shuttle-Programm im Juli 2011 nach drei Jahrzehnten.
| Nr. | Startdatum | Bezeichnung | Raumfähre | Startplatz | Landeplatz |
|---|---|---|---|---|---|
| 1 | 4/12/1981 | STS-1 | Columbia | LC-39A | Edwards Air Force Base |
| 2 | 11/12/1981 | STS-2 | Columbia | LC-39A | Edwards Air Force Base |
| 3 | 3/22/1982 | STS-3 | Columbia | LC-39A | White Sands Missile Range |
| 4 | 6/27/1982 | STS-4 | Columbia | LC-39A | Edwards Air Force Base |
| 5 | 11/11/1982 | STS-5 | Columbia | LC-39A | Edwards Air Force Base |
| 6 | 4/4/1983 | STS-6 | Challenger | LC-39A | Edwards Air Force Base |
| 7 | 6/18/1983 | STS-7 | Challenger | LC-39A | Edwards Air Force Base |
| 8 | 8/30/1983 | STS-8 | Challenger | LC-39A | Edwards Air Force Base |
| 9 | 11/28/1983 | STS-9 | Columbia | LC-39A | Edwards Air Force Base |
| 10 | 2/3/1984 | STS-41-B | Challenger | LC-39A | Kennedy Space Center |
| 11 | 4/6/1984 | STS-41-C | Challenger | LC-39A | Edwards Air Force Base |
| 12 | 8/30/1984 | STS-41-D | Discovery | LC-39A | Edwards Air Force Base |
| 13 | 10/5/1984 | STS-41-G | Challenger | LC-39A | Kennedy Space Center |
| 14 | 11/8/1984 | STS-51-A | Discovery | LC-39A | Edwards Air Force Base |
| 15 | 1/25/1985 | STS-51-C | Discovery | LC-39A | Edwards Air Force Base |
| 16 | 4/12/1985 | STS-51-D | Discovery | LC-39A | Edwards Air Force Base |
| 17 | 4/29/1985 | STS-51-B | Challenger | LC-39A | Edwards Air Force Base |
| 18 | 6/17/1985 | STS-51-G | Discovery | LC-39A | Edwards Air Force Base |
| 19 | 7/29/1985 | STS-51-F | Challenger | LC-39A | Edwards Air Force Base |
| 20 | 8/27/1985 | STS-51-I | Discovery | LC-39A | Edwards Air Force Base |
| 21 | 10/3/1985 | STS-51-J | Atlantis | LC-39A | Edwards Air Force Base |
| 22 | 10/30/1985 | STS-61-A | Challenger | LC-39A | Edwards Air Force Base |
| 23 | 11/27/1985 | STS-61-B | Atlantis | LC-39A | Edwards Air Force Base |
| 24 | 1/12/1986 | STS-61-C | Columbia | LC-39A | Edwards Air Force Base |
| 25 | 1/28/1986 | STS-51-L | Challenger | LC-39B | – |
| 26 | 9/29/1988 | STS-26 | Discovery | LC-39B | Edwards Air Force Base |
| 27 | 12/2/1988 | STS-27 | Atlantis | LC-39B | Edwards Air Force Base |
| 28 | 3/13/1989 | STS-29 | Discovery | LC-39B | Edwards Air Force Base |
| 29 | 5/4/1989 | STS-30 | Atlantis | LC-39B | Edwards Air Force Base |
| 30 | 8/8/1989 | STS-28 | Columbia | LC-39B | Edwards Air Force Base |
| 31 | 10/18/1989 | STS-34 | Atlantis | LC-39B | Edwards Air Force Base |
| 32 | 11/23/1989 | STS-33 | Discovery | LC-39B | Edwards Air Force Base |
| 33 | 1/9/1990 | STS-32 | Columbia | LC-39A | Edwards Air Force Base |
| 34 | 2/28/1990 | STS-36 | Atlantis | LC-39A | Edwards Air Force Base |
| 35 | 4/24/1990 | STS-31 | Discovery | LC-39B | Edwards Air Force Base |
| 36 | 10/6/1990 | STS-41 | Discovery | LC-39B | Edwards Air Force Base |
| 37 | 11/15/1990 | STS-38 | Atlantis | LC-39A | Kennedy Space Center |
| 38 | 12/2/1990 | STS-35 | Columbia | LC-39B | Edwards Air Force Base |
| 39 | 4/5/1991 | STS-37 | Atlantis | LC-39B | Edwards Air Force Base |
| 40 | 4/28/1991 | STS-39 | Discovery | LC-39A | Kennedy Space Center |
| 41 | 6/5/1991 | STS-40 | Columbia | LC-39B | Edwards Air Force Base |
| 42 | 8/2/1991 | STS-43 | Atlantis | LC-39A | Kennedy Space Center |
| 43 | 9/12/1991 | STS-48 | Discovery | LC-39A | Edwards Air Force Base |
| 44 | 11/24/1991 | STS-44 | Atlantis | LC-39B | Edwards Air Force Base |
| 45 | 1/22/1992 | STS-42 | Discovery | LC-39A | Edwards Air Force Base |
| 46 | 3/24/1992 | STS-45 | Atlantis | LC-39A | Kennedy Space Center |
| 47 | 5/7/1992 | STS-49 | Endeavour | LC-39B | Edwards Air Force Base |
| 48 | 6/25/1992 | STS-50 | Columbia | LC-39A | Kennedy Space Center |
| 49 | 7/31/1992 | STS-46 | Atlantis | LC-39B | Edwards Air Force Base |
| 50 | 9/12/1992 | STS-47 | Endeavour | LC-39B | Edwards Air Force Base |
| 51 | 10/22/1992 | STS-52 | Columbia | LC-39B | Edwards Air Force Base |
| 52 | 12/2/1992 | STS-53 | Discovery | LC-39A | Edwards Air Force Base |
| 53 | 1/13/1993 | STS-54 | Endeavour | LC-39B | Edwards Air Force Base |
| 54 | 4/8/1993 | STS-56 | Discovery | LC-39B | Kennedy Space Center |
| 55 | 4/26/1993 | STS-55 | Columbia | LC-39A | Edwards Air Force Base |
| 56 | 6/21/1993 | STS-57 | Endeavour | LC-39B | Edwards Air Force Base |
| 57 | 9/12/1993 | STS-51 | Discovery | LC-39B | Edwards Air Force Base |
| 58 | 10/18/1993 | STS-58 | Columbia | LC-39B | Edwards Air Force Base |
| 59 | 12/2/1993 | STS-61 | Endeavour | LC-39B | Kennedy Space Center |
| 60 | 2/3/1994 | STS-60 | Discovery | LC-39A | Kennedy Space Center |
| 61 | 3/4/1994 | STS-62 | Columbia | LC-39B | Kennedy Space Center |
| 62 | 4/9/1994 | STS-59 | Endeavour | LC-39A | Kennedy Space Center |
| 63 | 7/8/1994 | STS-65 | Columbia | LC-39A | Kennedy Space Center |
| 64 | 9/9/1994 | STS-64 | Discovery | LC-39B | Edwards Air Force Base |
| 65 | 9/30/1994 | STS-68 | Endeavour | LC-39A | Edwards Air Force Base |
| 66 | 11/3/1994 | STS-66 | Atlantis | LC-39B | Edwards Air Force Base |
| 67 | 2/3/1995 | STS-63 | Discovery | LC-39B | Kennedy Space Center |
| 68 | 3/2/1995 | STS-67 | Endeavour | LC-39A | Edwards Air Force Base |
| 69 | 6/27/1995 | STS-71 | Atlantis | LC-39A | Kennedy Space Center |
| 70 | 7/13/1995 | STS-70 | Discovery | LC-39B | Kennedy Space Center |
| 71 | 9/7/1995 | STS-69 | Endeavour | LC-39A | Kennedy Space Center |
| 72 | 10/20/1995 | STS-73 | Columbia | LC-39B | Kennedy Space Center |
| 73 | 11/12/1995 | STS-74 | Atlantis | LC-39A | Kennedy Space Center |
| 74 | 1/11/1996 | STS-72 | Endeavour | LC-39B | Kennedy Space Center |
| 75 | 2/22/1996 | STS-75 | Columbia | LC-39B | Kennedy Space Center |
| 76 | 3/22/1996 | STS-76 | Atlantis | LC-39B | Edwards Air Force Base |
| 77 | 5/19/1996 | STS-77 | Endeavour | LC-39B | Kennedy Space Center |
| 78 | 6/20/1996 | STS-78 | Columbia | LC-39B | Kennedy Space Center |
| 79 | 9/16/1996 | STS-79 | Atlantis | LC-39A | Kennedy Space Center |
| 80 | 11/19/1996 | STS-80 | Columbia | LC-39B | Kennedy Space Center |
| 81 | 1/12/1997 | STS-81 | Atlantis | LC-39B | Kennedy Space Center |
| 82 | 2/11/1997 | STS-82 | Discovery | LC-39A | Kennedy Space Center |
| 83 | 4/4/1997 | STS-83 | Columbia | LC-39A | Kennedy Space Center |
| 84 | 5/15/1997 | STS-84 | Atlantis | LC-39A | Kennedy Space Center |
| 85 | 7/1/1997 | STS-94 | Columbia | LC-39A | Kennedy Space Center |
| 86 | 8/7/1997 | STS-85 | Discovery | LC-39A | Kennedy Space Center |
| 87 | 9/26/1997 | STS-86 | Atlantis | LC-39A | Kennedy Space Center |
| 88 | 11/19/1997 | STS-87 | Columbia | LC-39B | Kennedy Space Center |
| 89 | 1/23/1998 | STS-89 | Endeavour | LC-39A | Kennedy Space Center |
| 90 | 4/17/1998 | STS-90 | Columbia | LC-39B | Kennedy Space Center |
| 91 | 6/2/1998 | STS-91 | Discovery | LC-39A | Kennedy Space Center |
| 92 | 10/29/1998 | STS-95 | Discovery | LC-39B | Kennedy Space Center |
| 93 | 12/4/1998 | STS-88 | Endeavour | LC-39A | Kennedy Space Center |
| 94 | 5/27/1999 | STS-96 | Discovery | LC-39B | Kennedy Space Center |
| 95 | 7/23/1999 | STS-93 | Columbia | LC-39B | Kennedy Space Center |
| 96 | 12/20/1999 | STS-103 | Discovery | LC-39B | Kennedy Space Center |
| 97 | 2/11/2000 | STS-99 | Endeavour | LC-39A | Kennedy Space Center |
| 98 | 5/19/2000 | STS-101 | Atlantis | LC-39A | Kennedy Space Center |
| 99 | 9/8/2000 | STS-106 | Atlantis | LC-39B | Kennedy Space Center |
| 100 | 10/11/2000 | STS-92 | Discovery | LC-39A | Edwards Air Force Base |
| 101 | 12/1/2000 | STS-97 | Endeavour | LC-39B | Kennedy Space Center |
| 102 | 2/7/2001 | STS-98 | Atlantis | LC-39A | Edwards Air Force Base |
| 103 | 3/8/2001 | STS-102 | Discovery | LC-39B | Kennedy Space Center |
| 104 | 4/19/2001 | STS-100 | Endeavour | LC-39A | Edwards Air Force Base |
| 105 | 7/12/2001 | STS-104 | Atlantis | LC-39B | Kennedy Space Center |
| 106 | 8/10/2001 | STS-105 | Discovery | LC-39A | Kennedy Space Center |
| 107 | 12/5/2001 | STS-108 | Endeavour | LC-39B | Kennedy Space Center |
| 108 | 3/1/2002 | STS-109 | Columbia | LC-39A | Kennedy Space Center |
| 109 | 4/8/2002 | STS-110 | Atlantis | LC-39B | Kennedy Space Center |
| 110 | 6/5/2002 | STS-111 | Endeavour | LC-39A | Edwards Air Force Base |
| 111 | 10/7/2002 | STS-112 | Atlantis | LC-39B | Kennedy Space Center |
| 112 | 11/24/2002 | STS-113 | Endeavour | LC-39A | Kennedy Space Center |
| 113 | 1/16/2003 | STS-107 | Columbia | LC-39A | – |
| 114 | 7/26/2005 | STS-114 | Discovery | LC-39B | Edwards Air Force Base |
| 115 | 7/4/2006 | STS-121 | Discovery | LC-39B | Kennedy Space Center |
| 116 | 9/9/2006 | STS-115 | Atlantis | LC-39B | Kennedy Space Center |
| 117 | 12/10/2006 | STS-116 | Discovery | LC-39B | Kennedy Space Center |
| 118 | 6/8/2007 | STS-117 | Atlantis | LC-39A | Edwards Air Force Base |
| 119 | 8/8/2007 | STS-118 | Endeavour | LC-39A | Kennedy Space Center |
| 120 | 10/23/2007 | STS-120 | Discovery | LC-39A | Kennedy Space Center |
| 121 | 2/7/2008 | STS-122 | Atlantis | LC-39A | Kennedy Space Center |
| 122 | 3/11/2008 | STS-123 | Endeavour | LC-39A | Kennedy Space Center |
| 123 | 5/31/2008 | STS-124 | Discovery | LC-39A | Kennedy Space Center |
| 124 | 11/15/2008 | STS-126 | Endeavour | LC-39A | Edwards Air Force Base |
| 125 | 3/15/2009 | STS-119 | Discovery | LC-39A | Kennedy Space Center |
| 126 | 5/11/2009 | STS-125 | Atlantis | LC-39A | Edwards Air Force Base |
| 127 | 7/15/2009 | STS-127 | Endeavour | LC-39A | Kennedy Space Center |
| 128 | 8/29/2009 | STS-128 | Discovery | LC-39A | Edwards Air Force Base |
| 129 | 11/16/2009 | STS-129 | Atlantis | LC-39A | Kennedy Space Center |
| 130 | 2/8/2010 | STS-130 | Endeavour | LC-39A | Kennedy Space Center |
| 131 | 4/5/2010 | STS-131 | Discovery | LC-39A | Kennedy Space Center |
| 132 | 5/14/2010 | STS-132 | Atlantis | LC-39A | Kennedy Space Center |
| 133 | 2/24/2011 | STS-133 | Discovery | LC-39A | Kennedy Space Center |
| 134 | 5/16/2011 | STS-134 | Endeavour | LC-39A | Kennedy Space Center |
| 135 | 7/8/2011 | STS-135 | Atlantis | LC-39A | Kennedy Space Center |
Das Space-Shuttle Programm der NASA endete im Juli 2011